Graduate School of Fisheries Sciences, Hokkaido University, Hakodate, Hokkaido 041-8611, Japan
We tried to convert the upstream chum salmon muscle and squid hepatopancreas, which are major marine by-products in northern Japan, to angiotensin I-converting enzyme (ACE) inhibitory peptides. Hydrolysates prepared from defatted chum salmon muscle and squid liver with some protease showed the inhibitory activity against ACE. When deffated chum salmon muscle was hydrolyzed for 2h at 37°C with 5% thermolysin, the inhibitory activity reached 73.0% at 78.9μg/mL. The yield of the hydrolysate was 86.9%.